High-throughput Cellular-resolution in Vivo Vertebrate Screening
نویسندگان
چکیده
Due to its small size and optical transparency, zebrafish larvae are excellent vertebrate models to study human diseases in vivo. We previously developed a high throughput screening platform capable of handling, cellular-resolution imaging and optically manipulating zebrafish larvae. Here, we present new novel technologies to significantly increase the throughput of our screening platform by multi-threading the loading and imaging processes and high-speed algorithms to automatically manipulate the larvae.
منابع مشابه
Fully automated cellular-resolution vertebrate screening platform with parallel animal processing.
The zebrafish larva is an optically-transparent vertebrate model with complex organs that is widely used to study genetics, developmental biology, and to model various human diseases. In this article, we present a set of novel technologies that significantly increase the throughput and capabilities of our previously described vertebrate automated screening technology (VAST). We developed a robu...
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